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Science: The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

作者:   发布于:2023年08月27日  点击量:495
Title:

The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation

Journal:Science
volume
Year:2021
Abstract:

During tumorigenesis, tumors must evolve to evade the immune system and do so by disrupting the genes involved in antigen processing and presentation or up-regulating inhibitory immune checkpoint genes. We performed in vivo CRISPR screens in syngeneic mouse tumor models to examine requirements for tumorigenesis both with and without adaptive immune selective pressure. In each tumor type tested, we found a marked enrichment for the loss of tumor suppressor genes (TSGs) in the presence of an adaptive immune system relative to immunocompromised mice. Nearly one-third of TSGs showed preferential enrichment, often in a cancer- and tissue-specific manner. These results suggest that clonal selection of recurrent mutations found in cancer is driven largely by the tumor’s requirement to avoid the adaptive immune system.

Cite/Figure:

cite

science.2021.373.issue-6561.data-cite


Links:

https://www.science.org/doi/10.1126/science.abg5784(如需全文,请联系我们)