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Nature Communications: Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

作者:   发布于:2023年08月09日  点击量:782
Title:

Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice

Journal:Nature COMMUNICATIONSvolume
Year:2017
Abstract

The aim of candidate universal influenza vaccines is to provide broad protection against influenza A and B viruses. Studies have demonstrated that broadly reactive antibodies require Fc–Fc gamma receptor interactions for optimal protection; however, the innate effector cells responsible for mediating this protection remain largely unknown. Here, we examine the roles of alveolar macrophages, natural killer cells, and neutrophils in antibody-mediated protection. We demonstrate that alveolar macrophages play a dominant role in conferring protection provided by both broadly neutralizing and non-neutralizing antibodies in mice. Our data also reveal the potential mechanisms by which alveolar macrophages mediate protection in vivo, namely antibody-induced inflammation and antibody-dependent cellular phagocytosis. This study highlights the importance of innate effector cells in establishing a broad-spectrum antiviral state, as well as providing a better understanding of how multiple arms of the immune system cooperate to achieve an optimal antiviral response following influenza virus infection or immunization.


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https://www.nature.com/articles/s41467-017-00928-3(如需全文,请联系我们)