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JCI: Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages

作者:   发布于:2023年08月09日  点击量:892
Title:

Inflammation-induced lymphangiogenesis  in the cornea arises from  CD11b-positive macrophages

Journal:JCI
volume
Year:2005
Abstract

In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved in the genesis of new lymphatic vessels. Our results indicate that innate immune cells (CD11b+ macrophages, but not CD11c+ dendritic cells) physically contributed to lymphangiogenesis under pathological conditions and that bone marrow–derived CD11b+ macrophages expressed lymphatic endothelial markers such as LYVE-1 and Prox-1 under inflamed conditions in the corneal stromata of mice. Furthermore, blood vascular endothelial cells that expressed the Tie2 promoter did not contribute to newly formed lymphatic vessels under inflamed conditions. Our in vitro experiments demonstrated that CD11b+ macrophages alone were capable of forming tube-like structures that expressed markers oflymphatic endothelium such as LYVE-1 and podoplanin. The novel finding thatCD11b+ macrophages are criticalfor the development ofinflammation-dependentlymphangiogenesis in the eye suggests a new mechanism of lymphangiogenesis.

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https://www.jci.org/articles/view/23874(如需全文,请联系我们)