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Cell: Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

作者:   发布于:2023年08月08日  点击量:369
Title:

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

Journal:

Cell

Year:2016
Abstract:

In obesity, macrophages and other immune cells accumulate in insulin target tissues, promoting a chronic inflammatory state and insulin resistance. Galectin-3 (Gal3), a lectin mainly secreted by macrophages, is elevated in both obese subjects and mice. Administration of Gal3 to mice causes insulin resistance and glucose intolerance, whereas inhibition of Gal3, through either genetic or pharmacologic loss of function, improved insulin sensitivity in obese mice. In vitro treatment with Gal3 directly enhanced macrophage chemotaxis, reduced insulin-stimulated glucose uptake in myocytes and 3T3-L1 adipocytes and impaired insulin-mediated suppression of glucose output in primary mouse hepatocytes. Importantly, we found that Gal3 can bind directly to the insulin receptor (IR) and inhibit downstream IR signaling. These observations elucidate a novel role for Gal3 in hepatocyte, adipocyte, and myocyte insulin resistance, suggesting that Gal3 can link inflammation to decreased insulin sensitivity. Inhibition of Gal3 could be a new approach to treat insulin resistance.



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Links
https://www.cell.com/cell/fulltext/S0092-8674(16)31445-3(如需全文,请联系我们)



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